Recent developments in myelodysplastic syndromes
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Review Series BONE MARROW FAILURE Recent developments in myelodysplastic syndromes
The myelodysplastic syndromes (MDS) represent the most common class of acquired bonemarrow failure syndromes in adults. Although MDSs are increasinglywell understood from a biological standpoint, including discovery of .40 MDS-associated recurrently mutated genes in the last 7 years, improved pathological insight has not yet translated into highly effective or curative therapies for most patien...
متن کاملMyelodysplastic Syndromes Myelodysplastic syndromes: recent advances
Etiology of myelodysplastic syndromes The models for the development of sporadic MDS suggest the role of cumulative environmental exposures in genetically predisposed individuals. There is increasing evidence for a complex genetic predisposition to MDS involving naturally occurring DNA polymorphisms in genes that mediate DNA repair and metabolize environmental carcinogens.3 Large epidemiologic ...
متن کاملMyelodysplastic syndromes: recent advances.
Response to fludarabine in B-cell chronic lymphocytic leukemia patients previously treated with chlorambucil as up-front therapy and a CHOP-like regimen as second line therapy
متن کاملRecent Advances in Myelodysplastic Syndromes
of risk. This importance is particularly stressed if the prognostic variability and aggressive nature of the currently available curative treatment options is taken into account, especially when considering the advanced age of the majority of patients. Although the French-American-British (FAB) classification has been relatively effective for categorizing MDS patients since 1982,1 its limitatio...
متن کامل[Recent advances in the treatment of myelodysplastic syndromes].
OBJECTIVES Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorder, which combine ineffective hematopoiesis and evolution to acute myeloid leukemia. Significant progress has been made in the understanding of the disease pathogenesis, diagnostics and classification. Promising new agents and innovative therapeutic strategies are currently used. In this article we will review th...
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ژورنال
عنوان ژورنال: Blood
سال: 2014
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2014-04-522136